(and and and and and = 3 biologically independent experiments. 1 (S6K1), which is a direct substrate of the mTORC1 kinase. Gratifyingly, when compared to the AAVS1 control sgRNA, loss of the hit genes decreased the phosphorylation of S6K1, suggesting that they likely act upstream of mTORC1 activity (Fig. 2and gene, which encodes a key … Continue reading (and and and and and = 3 biologically independent experiments